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Jake Bernstein

[Web: http://syntheticneurobiology.org/] [Email: jberns, followed by @media.mit.edu] [Phone: N/A]

Jake Bernstein joined the lab as an undergraduate during the Fall of his senior year, earned an S.B. in Physics at MIT, and is currently working towards a Ph.D. He has developed optical fiber arrays for independent multisite neural modulation, and deployed optical stimulators for many experiments in the lab, and in collaborating labs. He hopes to use his invention to parse the complex interactions of many brain regions which make up the neural circuit mediating a complex behavior.

Projects

Optogenetic hardware and systems for control of neural circuits and biological functions with light
Recording and data analysis technologies for observing and analyzing neural circuit dynamics
Understanding how neural circuits compute, drive behaviors, yield brain disorders, and can serve as therapeutic targets

Publications

Bernstein, J. G., Boyden, E. S. (2011) Optogenetic tools for analyzing the neural circuits of behavior, in press, Trends in Cognitive Sciences. doi:10.1016/j.tics.2011.10.003
Bernstein, J. G., Garrity, P. A.*, Boyden, E. S.* (2011) Optogenetics and thermogenetics: technologies for controlling the activity of targeted cells within intact neural circuits, Current Opinion in Neurobiology, in press, doi:10.1016/j.conb.2011.10.023. (* co-corresponding authors)
Kahn, I. * Desai, M., Knoblich, U., Bernstein, J., Henninger, M., Graybiel, A. M., Boyden, E. S.*, Buckner, R. L. *, Moore, C. I. * (2011) Characterization of the Functional MRI Response Temporal Linearity via Optical Control of Neocortical Pyramidal Neurons, Journal of Neuroscience 31(42):15086-15091. (* co-corresponding authors)
Wentz, C. T., Bernstein, J. G., Monahan, P., Guerra, A., Rodriguez, A., Boyden, E. S. (2011) A Wirelessly Powered and Controlled Device for Optical Neural Control of Freely-Behaving Animals, Journal of Neural Engineering 8(4): 046021 doi: 10.1088/1741-2560/8/4/046021
Chow, B. Y., Han, X., Bernstein, J. G., Monahan, P. E., Boyden, E. S. (2011) Light-Activated Ion Pumps and Channels for Temporally Precise Optical Control of Activity in Genetically Targeted Neurons, Chapter 6, Photosensitive Molecules for Controlling Biological Function, edited by James J. Chambers and Richard H. Kramer, Neuromethods Series Volume 55, 2011, DOI: 10.1007/978-1-61779-031-7, Humana Press.
Desai M., Kahn I., Knoblich U., Bernstein J., Atallah H., Yang A., Kopell, N., Buckner R.L., Graybiel A. M., Moore C. I.*, and Boyden E. S.* (2011) Mapping Brain Networks in Awake Mice Using Combined Optical Neural Control and fMRI, Journal of Neurophysiology 105(3):1393-405. (* co-corresponding authors)
Chan S. Y., Bernstein J. G., Boyden E. S. (2010). Scalable Fluidic Injector Arrays for Viral Targeting of Intact 3-D Brain Circuits. JoVE. 35. http://www.jove.com/index/details.stp?id=1489, doi: 10.3791/1489
Boyden, E. S., Han, X., Talei Franzesi, G., Chan, S., Bernstein, J., Qian, X., Li, M. (2009) "New Techniques for Investigating Brain Rhythms: Optical Neural Control and Multielectrode Recording," In: Rhythms of the Neocortex: Where Do They Come From and What Are They Good For? (Kopell N., ed.) pp. 65-75. Washington, DC: Society for Neuroscience.
Han, X.*, Qian, X., Bernstein, J.G., Zhou, H.-H., Talei Franzesi, G., Stern, P., Bronson, R.T., Graybiel, A.M., Desimone, R., and Boyden, E.S.* (2009) Millisecond-Timescale Optical Control of Neural Dynamics in the Nonhuman Primate Brain, Neuron 62(2): 191-198. (* co-corresponding authors)
Bernstein, J. G., Han, X., Henninger, M. A., Ko, E. Y., Qian, X., Franzesi, G. T., McConnell, J. P., Stern, P., Desimone, R., and Boyden, E. S. (2008) Prosthetic systems for therapeutic optical activation and silencing of genetically-targeted neurons. Proc Soc Photo Opt Instrum Eng, 6854:68540H.

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