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Xue Han

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Xue developed optical control neural technologies with the Synthetic Neurobiology group from the very beginning, working as a postdoctoral fellow. Beforehand, Xue did a Ph.D. at the University of Wisconsin, where she investigated the structure and dynamics of the initial structure formed between synaptic vesicles and the plasma membrane during calcium-trigged exocytosis, and she also did a brief postdoctoral fellowship at Stanford University where she studied how oculomotor events influence the primate visual system, as a Helen Hay Whitney Postdoctoral Fellow. Xue also recived a K99/R00 NIH Pathway to Independence Award. After finishing her work in the lab, Xue went on to start her own lab in 2010 at Boston University, as an assistant professor of bioengineering.

Projects

Understanding how neural circuits compute, drive behaviors, yield brain disorders, and can serve as therapeutic targets
Direct engineering and testing of novel therapeutic platforms for treatment of brain disorders
Optogenetic molecular reagents enabling control of the activity of targeted neurons and biological functions with light

Publications

McCarthy, M. M., Moore-Kochlacs, C., Xuan Gu, T., Boyden, E. S., Han, X., Kopell, N. J. (2011) Striatal origin of the pathologic beta oscillations in Parkinson’s disease, Proceedings of the National Academy of Sciences, 108(28):11620-5.
Han, X.*, Chow, B. Y.*, Zhou, H., Klapoetke, N. C., Chuong, A., Rajimehr, R., Yang, A., Baratta, M. V., Winkle, J., Desimone, R., Boyden, E. S. (2011) A high-light sensitivity optical neural silencer: development and application to optogenetic control of non-human primate cortex. Frontiers in Systems Neuroscience. 5:18. doi: 10.3389/fnsys.2011.00018 (* co-first authors)
Chow, B. Y., Han, X., Bernstein, J. G., Monahan, P. E., Boyden, E. S. (2011) Light-Activated Ion Pumps and Channels for Temporally Precise Optical Control of Activity in Genetically Targeted Neurons, Chapter 6, Photosensitive Molecules for Controlling Biological Function, edited by James J. Chambers and Richard H. Kramer, Neuromethods Series Volume 55, 2011, DOI: 10.1007/978-1-61779-031-7, Humana Press.
Chow, B. Y.*, Han, X.*, Dobry, A. S., Qian, X., Chuong, A. S., Li, M., Henninger, M. A., Belfort, G. M., Lin, Y., Monahan, P. E., Boyden, E. S. (2010) High-performance genetically targetable optical neural silencing by light- driven proton pumps, Nature 463:98-102. (* co-first authors)
Boyden, E. S., Han, X., Talei Franzesi, G., Chan, S., Bernstein, J., Qian, X., Li, M. (2009) "New Techniques for Investigating Brain Rhythms: Optical Neural Control and Multielectrode Recording," In: Rhythms of the Neocortex: Where Do They Come From and What Are They Good For? (Kopell N., ed.) pp. 65-75. Washington, DC: Society for Neuroscience.
Han X, Qian X, Stern P, Chuong A and Boyden ES (2009) Informational Lesions: Optical Perturbation of Spike Timing and Neural Synchrony Via Microbial Opsin Gene Fusions, Frontiers in Molecular Neuroscience, 2:12. doi:10.3389/neuro.02.012.2009
Han, X.*, Qian, X., Bernstein, J.G., Zhou, H.-H., Talei Franzesi, G., Stern, P., Bronson, R.T., Graybiel, A.M., Desimone, R., and Boyden, E.S.* (2009) Millisecond-Timescale Optical Control of Neural Dynamics in the Nonhuman Primate Brain, Neuron 62(2): 191-198. (* co-corresponding authors)
Boyden E, Franzesi G T, Qian X, Li M, Han X, Borgers C, Kopell N J, Le Beau F and Whittington M A (2009). Probing mechanisms of gamma rhythmogenesis with cell type-specific optical neural control. Frontiers in Systems Neuroscience. Conference Abstract: Computational and systems neuroscience. doi: 10.3389/conf.neuro.10.2009.03.299
Chow B, Han X, Qian X and Boyden E (2009). High-performance halorhodopsin variants for improved genetically-targetable optical neural silencing. Frontiers in Systems Neuroscience. Conference Abstract: Computational and systems neuroscience. doi: 10.3389/conf.neuro.10.2009.03.347
Bernstein, J. G., Han, X., Henninger, M. A., Ko, E. Y., Qian, X., Franzesi, G. T., McConnell, J. P., Stern, P., Desimone, R., and Boyden, E. S. (2008) Prosthetic systems for therapeutic optical activation and silencing of genetically-targeted neurons. Proc Soc Photo Opt Instrum Eng, 6854:68540H.
Han, X. and Boyden, E. S. (2007) Multiple-color optical activation, silencing, and desynchronization of neural activity, with single-spike temporal resolution, PLoS ONE 2(3): p. e299.
Han, X., and Boyden, E. S. (2007) Two-color, bi-directional optical voltage control of genetically-targeted neurons, Spotlight Presentation, at Computational and Systems Neuroscience (CoSyNe), Salt Lake City, UT, Feb 22-25, 2007.

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